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生物化學(xué)與分子生物學(xué)博導(dǎo)介紹
盛望
導(dǎo)師基本情況:
盛望,北京市特聘教授,生物醫(yī)學(xué)工程專業(yè)博士生導(dǎo)師。出生于1968年5月。1994年赴法國留學(xué),并與1996年和2001年分別獲得里昂第一大學(xué)病毒學(xué)碩士和病毒博士學(xué)位。2001-2005年在加拿大多倫多大學(xué)進行博士后研修。2005年10月受聘北京工業(yè)大學(xué)生命科學(xué)與生物工程學(xué)院特聘教授。
主要研究方向:
1. 病毒在腫瘤的發(fā)生和發(fā)展中的作用,及抗病毒藥物和疫苗的研究。
2. 干細胞的分化。
課題基金:
獲得北京市自然科學(xué)基金和北京市教委基金的資助
部份論文:
1.Sheng W, Wang G, La Pierre DP, Wen J, Deng Z, Wong CK, Lee DY, Yang BB. (2006) Versican Mediates Mesenchymal-Epithelial Transition. Mol Biol Cell. Apr;17(4):2009-20.
2.Sheng W, Wang G, Wang Y, Liang J, Wen J, Zheng PS, Wu Y, Lee V, Slingerland J, Dumont D, Yang BB.. (2005) The roles of versican v1 and v2 isoforms in cell proliferation and apoptosis. Mol Biol Cell. Mar;16(3):1330-40.
3.Sheng W., Bouguermouh A., Bouzid M., Djennaoui D. and Ooka T. (2004) BAM HI DNA Fragment H-Polymorphism of Epstein-Barr Virus is Associated with the Mutations Present in an 89 BP Sequence Localized in EBNA2 Gene. Virus Genes. Aug; 29(1): 99-108.
4.Sheng W., Decaussin G., Ligout A. and Ooka T. (2003) BARF1 gene encoded by Epstein-Barr virus contributes to the malignant phenotype and to apoptosis resistance in Burkitt's lymphoma cell line Akata. Journal of Virology, 77(6): 3859-65.
5.Sheng W., Decaussin G., Sumner S. and Ooka T. (2001) N-terminal domain of BARF1 gene encoded by Epstein-Barr virus is essential for malignant transformation of rodent fibroblasts and activation of BCL-2. Oncogene 20 (10): 1176-1185.
6.Wu Y. Sheng W. Cheng L Dong H., Lee V., Lu F., Wong C.S., Lu W. Y. and Yang B.B (2004) Versican V1 isoform induces neuronal differentiation and promotes neurite outgrowth. Mol Biol Cell. May; 15(5): 2093-104.
7.Wu Y., Chen L., Cao L., Sheng W. and Yang B.B. (2004) Overexpression of the C-terminal PG-M/versican domain impairs growth of tumor cells by intervening in the interaction between epidermal growth factor receptor and beta1-integrin. J Cell Sci. May 1; 117(Pt 11): 2227-37.
8.Zheng P. S., Wen J. P., Ang L. C., Sheng W., Viloria-petit A., Wang Y., Wu Y. Kerbel R. S.and Yang B.B. (2004) Versican/PG-M G3 domain promotes tumor growth and angiogenesis. FASEB J. Apr; 18(6): 754-6.
9.Kiani C., Chen L., Lee V., Zheng P.S., Wu Y., Cao L., Adams M.E., Sheng W. and Yang B.B. (2003) Identification of the motifs and amino acids in aggrecan G1 and G2 domains that inhibit product secretion. Biochemistry. Jun 17; 42(23): 7226-37.
10.Guo X., Sheng W., Zhang Y. Malignant transformation of monkey kidney epithelial cell induced by EBV BARF1 gene and TPA. . (2001) Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. Dec; 15(4): 321-3. Chinese.
11.Bouzid M., Sheng W., Buisson M., Bouguermouh A., Morand P., Seigneurin JM and Ooka T. (1998) Different distribution of H1-H2 Epstein-Barr virus variant in oropharyngeal virus and in biopsies of Hodgkin's disease and in nasopharyngeal carcinoma from Algeria. International Journal of Cancer 77(2): 205-210.
聯(lián)系方式:
Email: shengwang@bjut.edu.cn
Tel: 010-67392780
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